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dna damage repair ddr mechanisms  (Thermo Fisher)


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    Thermo Fisher dna damage repair ddr mechanisms
    Heat maps of DEGs involved in <t>DNA</t> <t>damage</t> repair <t>(DDR)</t> pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.
    Dna Damage Repair Ddr Mechanisms, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dna+damage+repair+ddr+mechanisms/pmc03793298-67-23-35?v=Thermo+Fisher
    Average 99 stars, based on 1 article reviews
    dna damage repair ddr mechanisms - by Bioz Stars, 2026-08
    99/100 stars

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    1) Product Images from "Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines"

    Article Title: Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines

    Journal: BioMed Research International

    doi: 10.1155/2013/746858

    Heat maps of DEGs involved in DNA damage repair (DDR) pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.
    Figure Legend Snippet: Heat maps of DEGs involved in DNA damage repair (DDR) pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.

    Techniques Used: Homologous Recombination, Generated, Microarray, Gene Expression, Comparison, Control, Cell Culture, Expressing, Derivative Assay



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    dna damage repair ddr mechanisms  (Thermo Fisher)
    99
    Thermo Fisher dna damage repair ddr mechanisms
    Heat maps of DEGs involved in <t>DNA</t> <t>damage</t> repair <t>(DDR)</t> pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.
    Dna Damage Repair Ddr Mechanisms, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dna+damage+repair+ddr+mechanisms/pmc03793298-67-23-35?v=Thermo+Fisher
    Average 99 stars, based on 1 article reviews
    dna damage repair ddr mechanisms - by Bioz Stars, 2026-08
    99/100 stars
    		  Buy from Supplier

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    Heat maps of DEGs involved in DNA damage repair (DDR) pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.

    Journal: BioMed Research International

    Article Title: Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines

    doi: 10.1155/2013/746858

    Figure Lengend Snippet: Heat maps of DEGs involved in DNA damage repair (DDR) pathways deregulated in hypoxia. Clustering of DEGs involved in DNA damage repair (DDR) pathways: mismatch repair (MMR), nucleotide excision repair (NER), nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR). The heat maps were generated from microarray data reflecting gene expression values in MCF-7, MDA-MB-231, and SKBr3 cells exposed to hypoxia (3% O 2 ) for 24 h and 48 h in comparison to control cells cultured under normoxic conditions (16% O 2 , M > |1| and P < 0.05). Each row represents the expression levels for a single gene tested for different experimental conditions. Each column shows the expression levels for the genes tested for a single experimental condition. The absolute expression value (log scale) of each gene is derived from the mean of two biological replicates. The color scale bar on the top represents signal intensity variations ranging from green (poorly expressed genes) to red (highly expressed genes). Black boxes indicate intermediate expression values. N = normoxia; H24 = hypoxia for 24 h; H48 = hypoxia for 48 h.

    Article Snippet: Since hypoxia is a condition which during tumor growth influences the expression of several genes involved in angiogenesis, proliferation, cell cycle control, and DNA damage repair (DDR) mechanisms, we first performed a microarray analysis, using Affymetrix platform, in order to compare differential gene expression profiles in MCF-7, MDA-MB-231, and SKBr3 human breast cancer cell lines in response to hypoxic exposure for 24 and 48 hours, respectively.

    Techniques: Homologous Recombination, Generated, Microarray, Gene Expression, Comparison, Control, Cell Culture, Expressing, Derivative Assay